Protein Modification Reagents
Medchemexpress LLC m-PEG15-NHS ester | 98.0% | 50 MG
m-PEG15-NHS ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Medchemexpress LLC Methyltetrazine-PEG8-NHS ester | 2183440-34-6 | MFCD31580145 | 99.3% | C32H47N5O13 | 10MG
Methyltetrazine-PEG8-NHS ester is a PEG-based linker bearing a methyltetrazine group and an N-hydroxysuccinimide (NHS) activated ester. It enables rapid bioorthogonal conjugation via inverse electron-demand Diels-Alder chemistry on the tetrazine side and efficient amine coupling through the NHS ester, making it suitable for PROTAC assembly and general bioconjugation in research applications.
- Methyltetrazine reactive handle enables fast bioorthogonal cycloaddition.
- NHS ester allows straightforward amine conjugation under mild conditions.
- PEG8 spacer improves aqueous solubility and reduces steric hindrance.
- High purity supports reliable synthetic and bioconjugation workflows.
- Compatible with linker assembly and PROTAC synthesis workflows.
Medchemexpress LLC DSPE-PEG-SH | 1462982-18-8 | 90.0% | 1,000 Da | C44H86NO10PS | 250 MG
DSPE-PEG-SH (MW 1000) is a thiol-terminated PEGylated phospholipid reagent used to introduce free thiol groups onto liposome or nanoparticle surfaces for subsequent bioconjugation. It is supplied for research use in small laboratory pack sizes and is commonly employed in formulation, surface modification, and targeted delivery workflows.
- Thiol functional group for conjugation to maleimide reagents.
- Average molecular weight of approximately 1,000 Da.
- Amphiphilic phospholipid-PEG structure for incorporation into lipid bilayers.
- Enables surface modification of liposomes and nanoparticles.
- Supplied in small research pack sizes for laboratory use.
- Typical reported purity around 90%.
Medchemexpress LLC (S,R,S)-AHPC-PEG2-C4-Cl | 1835705-57-1 | MFCD31560480 | 98.2% | 651.26 g/mol | C32H47ClN4O6S | 2 G
A VHL ligand-linker conjugate used as a PROTAC building block; it incorporates the (S,R,S)-AHPC VHL ligand connected via a PEG2-C4 alkyl/ether linker with a terminal chloride and has been reported to induce degradation of GFP-HaloTag7 in cell-based assays.
- Used as a building block for PROTAC synthesis and E3 ligase ligand-linker conjugates.
- Contains a VHL-binding (S,R,S)-AHPC motif with a PEG2-C4 linker.
- Reported to induce GFP-HaloTag7 degradation in cell assays.
- Soluble in DMSO, water, and ethanol at approximately 50 mg/mL (may require ultrasonic).
- Available in multiple package sizes, including a 2 g option.
Medchemexpress LLC Azido-AHPC-PEG3 (VHL ligand-linker) pyrrolidine-2-carboxamide | 1797406-80-4 | MFCD31807299 | ≥95.0% | 645.77 g/mol | C30H43N7O7S | 10 MG
(S,R,S)-AHPC-PEG3-N3 is an E3 ligase ligand-linker conjugate that couples an (S,R,S)-AHPC VHL-binding motif to a three-unit PEG linker terminated with an azide. It is intended as a click-chemistry reagent for PROTAC synthesis and bioconjugation, enabling covalent linkage to alkyne-bearing partners.
- Molecular weight 645.77 g/mol.
- Chemical formula C30H43N7O7S.
- CAS number 1797406-80-4.
- Purity ≥95%.
- Suitable for CuAAC and SPAAC click reactions.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Soluble in ethanol, water, and DMSO at concentrations commonly used for bioconjugation.
eMolecules Diketone-PEG12-DBCO | Broadpharm |1092.290 | C58H81N3O17 | 0.000 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 10mg | 462125387
Diketone-PEG12-DBCO | Broadpharm |1092.290 | C58H81N3O17 | 0.000 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 10mg | 462125387
Medchemexpress LLC (S,R,S)-AHPC-PEG2-NH2 dihydrochloride | 2341796-76-5 | 648.64 g/mol | C28H43Cl2N5O6S | 100 MG
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride is a VHL E3 ligase ligand-linker conjugate used as a building block in PROTAC synthesis. It combines an (S,R,S)-configured AHPC VHL ligand with a two-unit PEG linker terminating in a primary amine and is supplied as a dihydrochloride salt in powder form for research use.
- VHL ligand-linker conjugate for PROTAC assembly.
- Two-unit PEG linker with terminal primary amine.
- Dihydrochloride salt stable as a sealed powder.
- Supplied in small milligram quantities for medicinal chemistry workflows.
- Suitable as a synthetic building block in degrader design.
Medchemexpress LLC Nh2-peg4-dota | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 50mg
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 100 MG
Azide-PEG4-VC-PAB-doxorubicin is an azide-functionalized drug-linker conjugate that links the cytotoxic agent doxorubicin to a PEG4-VC-PAB linker for use in antibody-drug conjugate synthesis and click chemistry applications.
- High purity (99.62%).
- Molecular weight 1222.25 g/mol.
- Chemical formula C57H75N9O21.
- Orange to red solid appearance.
- Storage: powder at -20°C (long term) or 4°C (short term); in solvent at -80°C or -20°C as recommended.
- Available as solid (1-100 mg) and 10 mM solution in DMSO.
Medchemexpress LLC 1,2,4,5-Tetrazine, 3-methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]- | 1802907-97-6 | 98.0% | C20H26N4O5 | 25 MG
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules composed of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a protein of interest. They function by exploiting the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- Functions as a PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 (Average) | 5 MG
DSPE-PEG-folate (average MW 2000) is a PEGylated lipid conjugate in which a DSPE lipid is linked to polyethylene glycol terminating in folate. Supplied as a solid powder for research use, it is used to introduce folate targeting moieties onto liposomes, micelles, and nanoparticle surfaces to enable receptor-mediated delivery to folate receptor-expressing cells. Typical storage: powder at -20°C; in solvent store at -80°C for long-term stability.
- Provides folate-mediated targeting to folate receptor-expressing cells.
- Suitable for incorporation into liposomes, micelles, and nanoparticle surfaces.
- Average molecular weight approximately 2000 Da.
- Supplied as a solid powder for laboratory research use.
- Purity approximately 90.0% as provided by the manufacturer.
- Storage recommendations included for powder and in-solution conditions.
Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 1 ML
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Incorporates an (S,R,S)-AHPC-based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target proteins
Medchemexpress LLC Propanoic acid, 3-(2-bromoethoxy)- | 1393330-33-0 | 98.0% | 100 MG
Bromo-PEG1-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Functions as a PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- High purity of 98.0%
- Appears as a liquid, ranging from light yellow to yellow
- Requires storage at -20°C, protected from light
